Specific N-Linked Glycosylation Patterns in Areas of Necrosis in Tumor Tissues.

ABSTRACT: Tissue necrosis is a form of cell death common in advanced and aggressive solid tumors, and is associated with areas of intratumoral chronic ischemia. The histopathology of necrotic regions appear as a scaffold of cellular membrane remnants, reflective of the hypoxia and cell degradation events associated with this cellular death pathway. Changes in the glycosylation of cell surface proteins is another common feature of cancer progression. Using a recently developed mass spectrometry imaging approach to evaluate N-linked glycan distributions in human formalin-fixed clinical cancer tissues, differences in the glycan structures of regions of tumor, stroma and necrosis were evaluated. While the structural glycan classes detected in the tumor and stromal regions are typically classified as hig

SUBMITTER: Scott DA 

PROVIDER: S-EPMC6483403 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature