Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets.

ABSTRACT: Macrophages are well recognized for their dual roles in orchestrating inflammatory responses and regulating tissue repair. In almost all acutely inflamed tissues, 2 main subclasses of macrophages coexist. These include embryonically derived resident tissue macrophages and BM-derived recruited macrophages. While it is clear that macrophage subsets categorized in this fashion display distinct transcriptional and functional profiles, whether all cells within these categories and in the same inflammatory microenvironment share similar functions or whether further specialization exists has not been determined. To investigate inflammatory macrophage heterogeneity on a more granular level, we induced acute lung inflammation in mice and performed single cell RNA sequencing of macrophages isolated

SUBMITTER: Mould KJ 

PROVIDER: S-EPMC6483508 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature