Dysregulated Maturation of the Functional Connectome in Antipsychotic-Naive, First-Episode Patients With Adolescent-Onset Schizophrenia.

ABSTRACT:

Background

Schizophrenia has been conceptualized as a brain network disorder rooted in dysregulated neurodevelopmental processes. Recent neuroimaging studies revealed disrupted brain connectomic organization in adult schizophrenia patients. However, altered developmental trajectories of the functional connectome during the adolescent maturational stage have not been examined.

Methods

The present study combined functional MRI with a graph theoretical approach to examine functional network topology and its age-related development in 39 medication naïve, first-episode patients with adolescent-onset schizophrenia and 31 matched controls (age range: 12-18 years).

Results

Patients demonstrated impaired large-scale integration as reflected by reduced global efficiency as wel

SUBMITTER: Li M 

PROVIDER: S-EPMC6483582 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature