Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis.

ABSTRACT:

Objective

Increasingly, studies have identified abnormalities in the functional connectivity (FC) of large-scale neural networks in early psychosis, but the findings thus far have been inconclusive. Therefore, the aim of this study was to identify robust alterations in FC of the default mode (DMN), salience (SN), and central executive networks (CEN), in patients with first-episode psychosis (FEP) using a meta-analytic approach.

Methods

Included studies were required to be resting-state, seed-to-whole brain, FC neuroimaging studies, comparing FEP patients to healthy controls (HC), with seeds within the boundaries of the region-of-interest networks. Peak effect coordinates and peak t, z, or p values were meta-analyzed using Seed-based d Mapping software.

Results

The DMN

SUBMITTER: O'Neill A 

PROVIDER: S-EPMC6483589 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature