Anterior Cingulate Glutamate and GABA Associations on Functional Connectivity in Schizophrenia.

ABSTRACT:

Background

The underlying neurobiological mechanism for abnormal functional connectivity in schizophrenia (SCZ) remains unknown. This project investigated whether glutamate and GABA, 2 metabolites that contribute to excitatory and inhibitory functions, may influence functional connectivity in SCZ.

Methods

Resting-state functional magnetic resonance imaging and proton magnetic resonance spectroscopy were acquired from 58 SCZ patients and 61 healthy controls (HC). Seed-based connectivity maps were extracted between the anterior cingulate cortex (ACC) spectroscopic voxel and all other brain voxels. Magnetic resonance spectroscopy (MRS) spectra were processed to quantify glutamate and GABA levels. Regression analysis was performed to describe relationships between functional con

SUBMITTER: Shukla DK 

PROVIDER: S-EPMC6483591 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature