Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center-Follicular Helper T Cells.

ABSTRACT:

Objective

CD4 germinal center (GC)-follicular helper T (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor (A2aR; Adora2a) signaling can divert CD4 T cells away from the GC-Tfh cell lineage during the primary response to foreign antigens. This study was undertaken to examine the effects of A2aR signaling on CD4 T cells during the recognition of self antigen in a murine model of autoimmune arthritis.

Methods

Wild-type and Adora2a-deficient mouse KRN T cell receptor-transgenic CD4 T cells specific for glucose-6-phosphate isomerase (GPI)/I-A^g7 were transferred into immunodeficient Tcra^-/- I-A^g7 -expressing mice to induce arthritis. Recipients were then treated with either

SUBMITTER: Schmiel SE 

PROVIDER: S-EPMC6483839 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature