Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca²⁺-ATPase in Heart Failure.

ABSTRACT:

Rationale

SERCA2a, sarco-endoplasmic reticulum Ca²⁺-ATPase, is a critical determinant of cardiac function. Reduced level and activity of SERCA2a are major features of heart failure. Accordingly, intensive efforts have been made to develop efficient modalities for SERCA2a activation. We showed that the activity of SERCA2a is enhanced by post-translational modification with SUMO1 (small ubiquitin-like modifier 1). However, the roles of other post-translational modifications on SERCA2a are still unknown.

Objective

In this study, we aim to assess the role of lysine acetylation on SERCA2a function and determine whether inhibition of lysine acetylation can improve cardiac function in the setting of heart failure.

Methods and results

The acetylation of SERCA2a was

SUBMITTER: Gorski PA 

PROVIDER: S-EPMC6483854 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature