Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

ABSTRACT:

Rationale

After a stroke, patients frequently experience altered systemic immunity resulting in peripheral immunosuppression and higher susceptibility to infections, which is at least partly attributed to lymphopenia. The mechanisms that profoundly change the systemic leukocyte repertoire after stroke are incompletely understood. Emerging evidence indicates that stroke alters hematopoietic output of the bone marrow.

Objective

To explore the mechanisms that lead to defects of B lymphopoiesis after ischemic stroke.

Methods and results

We here report that ischemic stroke triggers brain-bone marrow communication via hormonal long-range signals that regulate hematopoietic B lineage decisions. Bone marrow fluorescence-activated cell sorter analyses and serial intravital mic

SUBMITTER: Courties G 

PROVIDER: S-EPMC6483874 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature