The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.

ABSTRACT: Metabolic coherence (MC) is a network-based approach to dimensionality reduction that can be used, for example, to interpret the joint expression of genes linked to human metabolism. Computationally, the derivation of 'transcriptomic' MC involves mapping of an individual gene expression profile onto a gene-centric network derived beforehand from a metabolic network (currently Recon2), followed by the determination of the connectivity of a particular, profile-specific subnetwork. The biological significance of MC has been exemplified previously in the context of human inflammatory bowel disease, among others, but the genetic architecture of this quantitative cellular trait is still unclear. Therefore, we performed a genome-wide association study (GWAS) of MC in the 1000 Genomes/ GEUVADIS da

SUBMITTER: Schlicht K 

PROVIDER: S-EPMC6483969 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature