The chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) controls cellular quiescence by hyperpolarizing the cell membrane during diapause in the crustacean Artemia.

ABSTRACT: Cellular quiescence, a reversible state in which growth, proliferation, and other cellular activities are arrested, is important for self-renewal, differentiation, development, regeneration, and stress resistance. However, the physiological mechanisms underlying cellular quiescence remain largely unknown. In the present study, we used embryos of the crustacean Artemia in the diapause stage, in which these embryos remain quiescent for prolonged periods, as a model to explore the relationship between cell-membrane potential (V_mem) and quiescence. We found that V_mem is hyperpolarized and that the intracellular chloride concentration is high in diapause embryos, whereas V_mem is depolarized and intracellular chloride concentration is

SUBMITTER: Li AQ 

PROVIDER: S-EPMC6484108 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature