Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure.

ABSTRACT: Secondhand smoke remains a global concern for children's health. Epidemiological studies implicate exposure to secondhand smoke as a major risk factor for behavioral disorders, yet biological causation remains unclear. Model studies have mainly focused on secondhand smoke impacts to prenatal neurodevelopment, yet juvenile exposure represents a separate risk. Using ion mobility-enhanced data-independent mass spectrometry, the effect of juvenile secondhand smoke exposure on the prefrontal cortex, a principal part of the brain involved in behavioral control, is characterized. The produced dataset includes 800 significantly responsive proteins within the juvenile orbital frontal cortex, with 716 showing an increase in abundance. The neuroproteomic response reflects a prominent perturbation wit

SUBMITTER: Lewis LSC 

PROVIDER: S-EPMC6484431 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature