Progression of the canonical reference malaria parasite genome from 2002-2019.

ABSTRACT: Here we describe the ways in which the sequence and annotation of the Plasmodium falciparum reference genome has changed since its publication in 2002. As the malaria species responsible for the most deaths worldwide, the richness of annotation and accuracy of the sequence are important resources for the P. falciparum research community as well as the basis for interpreting the genomes of subsequently sequenced species. At the time of publication in 2002 over 60% of predicted genes had unknown functions. As of March 2019, this number has been significantly decreased to 33%. The reduction is due to the inclusion of genes that were subsequently characterised experimentally and genes with significant similarity to others with known functions. In addition, the structural annotati

SUBMITTER: Bohme U 

PROVIDER: S-EPMC6484455 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature