Association of Subthalamic Deep Brain Stimulation With Motor, Functional, and Pharmacologic Outcomes in Patients With Monogenic Parkinson Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Comparative outcomes among different monogenic forms of Parkinson disease after subthalamic nucleus deep brain stimulation (STN DBS) remain unclear.

Objective

To compare clinical outcomes in patients with the most common monogenic forms of Parkinson disease treated with STN DBS.

Design, setting, and participants

Systematic review and meta-analysis in which a PubMed search of interventional and noninterventional studies of Parkinson disease with LRRK2, GBA, or PRKN gene mutations published between January 1, 1990, and May 1, 2018, was conducted. Among the inclusion criteria were articles that reported the Motor subscale of the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) before and after STN DBS treatment, that involved human participants, a

SUBMITTER: Artusi CA 

PROVIDER: S-EPMC6484599 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature