Pre-pregnancy kidney function and subsequent adverse pregnancy outcomes.

ABSTRACT:

Background

Renal insufficiency is associated with pregnancy complications including fetal growth restriction, preterm birth (PTB), and pre-eclampsia.

Objective

To determine the effect of preconception kidney function within the normal range on pregnancy outcome.

Method

1043 (50% black, 50% white) women who participated in the CARDIA study who had kidney function and biochemical analyses measured before at least one pregnancy delivered during the 20 years post-baseline period were included in analysis. Kidney function estimated as glomerular filtration rate (eGFR) via modified CKD-EPI equations, serum creatinine, and urinary albumin/creatinine ratio were evaluated as predictors of infant birthweight, gestational age, birthweight-for-gestational-age, and hypertensive di

SUBMITTER: Harville EW 

PROVIDER: S-EPMC6484837 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature