Hierarchical modeling of melanocortin 1 receptor variants with skin cancer risk.

ABSTRACT: The human MC1R gene is highly polymorphic among lightly pigmented populations, and several variants in the MC1R gene have been associated with increased risk of both melanoma and nonmelanoma skin cancers. The functional consequences of MC1R gene variants have been studied in vitro and in vivo in postulated causal pathways, such as G-protein-coupled signaling transduction, pigmentation, immune response, inflammatory response, cell proliferation, and extracellular matrix adhesion. In a case-control study nested within the Nurses' Health Study, we utilized hierarchical modeling approaches, incorporating quantitative information from these functional studies, to examine the association between particular MC1R alleles and the risk of skin cancers. Different prior matrices were constructed accor

SUBMITTER: Joshi AD 

PROVIDER: S-EPMC6484855 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature