Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.

ABSTRACT:

Background

Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstrate that it is possible to harness the physiological properties of the lymphatic system to optimize the induction of a protective T cell response. Indeed, the lymphatic system sharply distinguishes between nanoscale and microscale particles. The former reaches the fenestrated lymphatic system via diffusion, while the latter either need to be transported by dendritic cells or form a local depot.

Methods

Our previously developed cucumber-mosaic virus-derived nanoparticles termed (CuMV_TT-VLPs) incorporating a universal Tetanus toxo

SUBMITTER: Mohsen MO 

PROVIDER: S-EPMC6485085 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature