Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons.

ABSTRACT:

Background

Promyelocytic leukemia zinc finger (Plzf), a transcriptional regulator involved in a lot of important biological processes during development, has been implied to maintain neural stem cells and inhibit their differentiation into neurons. However, the effects of Plzf on brain structures and functions are still not clarified.

Results

We showed that Plzf expression was detected as early as embryonic day (E) 9.5 in Pax6⁺ cells in the mouse brain, and was completely disappeared in telencephalon before the initiation of cortical neurogenesis. Loss of Plzf resulted in a smaller cerebral cortex with a decrease in the number of Tbr1⁺ deep layer neurons due to a decrease of mitotic cell number in the ventricular zone of forebrain at early developmental

SUBMITTER: Lin HC 

PROVIDER: S-EPMC6485146 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature