Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [¹⁸F]DPA-714 PET and MRI.

ABSTRACT: Background: Activation and dysregulation of innate, adaptive and resident immune cells in response to damage determine the pathophysiology of demyelinating disorders. Among the plethora of involved cells, microglia/macrophages and astrocytes play an important role in the pathogenesis of demyelinating disorders. The in-depth investigation of the spatio-temporal profile of these cell types in vivo may inform about the exact disease state and localization as well as may allow to monitor therapeutic modulation of the components of the neuroinflammatory response during the course of multiple sclerosis (MS). In this study, we aimed to non-invasively decipher the degree and temporal profile of neuroinflammation (TSPO - [¹⁸F]DPA-714 PET) in relation to selected magnetic re

SUBMITTER: Zinnhardt B 

PROVIDER: S-EPMC6485187 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature