Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells.

ABSTRACT: Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labelling of Annexin V. The Annexin V-BASHY conjugate maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.

SUBMITTER: Cal PM 

PROVIDER: S-EPMC6485347 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature