Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men.

ABSTRACT:

Background

Weight gain and metabolic changes during treatment with antidepressant drugs have emerged as an important concern, particularly in long-term treatment. It is still a matter of ongoing debate whether weight gain and metabolic perturbations with antidepressant use are the consequence of increased appetite and weight gain, respectively, or represents direct pharmacological effects of the drug on metabolism.

Methods

We therefore conducted a proof-of-concept, open-label clinical trial, hypothesizing that in exceptionally healthy men no change of metabolic parameters would occur under mirtazapine, when environmental factors such as nutrition, sleep, and physical exercise were controlled and kept constant. Over a 3-week preparation phase, 10 healthy, young men were attun

SUBMITTER: Hennings JM 

PROVIDER: S-EPMC6485362 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature