Population structure of invasive Neisseria meningitidis in the United States, 2011-15.

ABSTRACT:

Objectives

Meningococcal conjugate vaccines (MenACWY) were licensed in the United States in 2005. We assessed the population structure of invasive Neisseria meningitidis (Nm) ten years after recommended use of MenACWY among adolescents.

Methods

Meningococcal isolates obtained through Active Bacterial Core surveillance (ABCs) from 2000-05, 2006-10, and 2011-15 underwent whole genome or Sanger sequencing. Genome phylogenies were completed using maximum likelihood methods; and distribution of multilocus sequence typing (MLST) sequence type (ST) and clonal complex (CC), and PorA and FetA types were assessed.

Results

Prevalent serogroups (B, C, Y and W), CCs, and PorA and FetA types were detected in all three time periods, but dynamic changes were observed. The proportion

SUBMITTER: Potts CC 

PROVIDER: S-EPMC6485409 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature