HnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.

ABSTRACT: Largely owing to widespread deployment of microarray analysis, many of the transcriptional events associated with invasive cell migration are becoming clear. However, the transcriptional drives to invasive migration are likely modified by alternative splicing of pre-mRNAs to produce functionally distinct patterns of protein expression. Heterogenous nuclear ribonucleoprotein (hnRNP A2) is a known regulator of alternative splicing that is upregulated in a number of invasive cancer types. Here, we report that although siRNA of hnRNP A2 had little influence on the ability of cells to migrate on plastic surfaces, the splicing regulator was clearly required for cells to move effectively on three-dimensional matrices and to invade into plugs of extracellular matrix proteins. We used exon-tiling m

SUBMITTER: Moran-Jones K 

PROVIDER: S-EPMC6485436 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature