Dataset Information

Antibiotics for treating scrub typhus.

ABSTRACT:

SUBMITTER: El Sayed I

PROVIDER: S-EPMC6485465 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Antibiotics for treating scrub typhus.

El Sayed Iman I Liu Qin Q Wee Ian I Hine Paul P

The Cochrane database of systematic reviews 20180924

<h4>Background</h4>Scrub typhus, an important cause of acute fever in Asia, is caused by Orientia tsutsugamushi, an obligate intracellular bacterium. Antibiotics currently used to treat scrub typhus include tetracyclines, chloramphenicol, macrolides, and rifampicin.<h4>Objectives</h4>To assess and compare the effects of different antibiotic regimens for treatment of scrub typhus.<h4>Search methods</h4>We searched the following databases up to 8 January 2018: the Cochrane Infectious Diseases Grou ...[more]

PMID: 30246875

Similar Datasets

Project description:ImportanceAntibiotics have been used for many years to treat scrub typhus, but their efficacy and safety have not been studied thoroughly.ObjectiveTo compare and rank different antibiotics to identify which one can safely eliminate Orientia tsutsugamushi and efficiently alleviate fever in patients with scrub typhus.Data sourcesAn electronic search of PubMed and Embase was conducted, from database inception to July 12, 2019. The study was conducted from July 12 to September 2, 2019.Study selectionRandomized clinical trials and retrospective studies that evaluated the use of antibiotics for treatment in patients diagnosed with scrub typhus caused by O tsutsugamushi were included. Records of articles in English were considered eligible. Studies were assessed independently by 2 reviewers, with disagreement resolved by consensus. Of 6408 studies initially identified, 10 randomized clinical trials and 4 retrospective study met the criteria for further analysis.Data extraction and synthesisThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension statement for systematic reviews incorporating network meta-analyses of health care interventions. Data were independently extracted by 2 reviewers and synthesized with frequentist random-effects network meta-analyses.Main outcomes and measuresThe primary outcome was efficacy of the antibiotic, considered as the number of patients who achieved complete healing with an antibiotic. Safety, defined as the prevalence of adverse events associated with the antibiotics, was the secondary outcome, and defervescence time was the tertiary outcome. P scores (scale of 0 to 1, with 1 indicating superiority to other treatments) were used to rank the efficacy, safety, and defeverescence time of the antibiotics.ResultsThree searches for articles in Embase and PubMed identified 10 randomized clinical trials (888 participants) and 4 retrospective studies (323 participants) for further analyses. No particular treatment regimen showed a significant advantage or disadvantage with regard to efficacy or safety. However, meta-analysis of retrospective studies indicated that clarithromycin (P score = 0.8730) alleviated fever more efficiently than other antibiotics.Conclusions and relevanceNo treatment regimen reported in this network meta-analysis showed a significant advantage or disadvantage with regard to efficacy or safety. However, clarithromycin might be a better choice than the other drugs for alleviating fever.

Dataset Information

Antibiotics for treating scrub typhus.

Publications

Antibiotics for treating scrub typhus.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets