Human PAH is characterized by a pattern of lipid-related insulin resistance.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a deadly disease of the small pulmonary vasculature with an increased prevalence of insulin resistance (IR). Insulin regulates both glucose and lipid homeostasis. We sought to quantify glucose- and lipid-related IR in human PAH, testing the hypothesis that lipoprotein indices are more sensitive indices of IR in PAH.

Methods

Oral glucose tolerance testing in PAH patients and triglyceride-matched (TG-matched) controls and proteomic, metabolomics, and lipoprotein analyses were performed in PAH and controls. Results were validated in an external cohort and in explanted human PAH lungs.

Results

PAH patients were similarly glucose intolerant or IR by glucose homeostasis metrics compared with control patients when matched f

SUBMITTER: Hemnes AR 

PROVIDER: S-EPMC6485674 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature