Neural control of body-plan axis in regenerating planaria.

ABSTRACT: Control of axial polarity during regeneration is a crucial open question. We developed a quantitative model of regenerating planaria, which elucidates self-assembly mechanisms of morphogen gradients required for robust body-plan control. The computational model has been developed to predict the fraction of heteromorphoses expected in a population of regenerating planaria fragments subjected to different treatments, and for fragments originating from different regions along the anterior-posterior and medio-lateral axis. This allows for a direct comparison between computational and experimental regeneration outcomes. Vector transport of morphogens was identified as a fundamental requirement to account for virtually scale-free self-assembly of the morphogen gradients observed in planarian hom

SUBMITTER: Pietak A 

PROVIDER: S-EPMC6485777 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature