Ontology highlight
ABSTRACT:
SUBMITTER: Shokri L
PROVIDER: S-EPMC6485956 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell reports 20190401 3
Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 protein-protein interactions (PPIs), more than doubling the number of currently known PPIs among Drosophila TFs. For quality assessment, we validated a subset of our interactions using MITOMI and bimolecular fluorescence complementation assays. W ...[more]