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Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia.

ABSTRACT:

SUBMITTER: Bauer K

PROVIDER: S-EPMC6485963 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia.

Bauer Kathrin K Rancea Michaela M Roloff Verena V Elter Thomas T Hallek Michael M Engert Andreas A Skoetz Nicole N

The Cochrane database of systematic reviews 20121114

<h4>Background</h4>Chronic lymphocytic leukaemia (CLL) accounts for 25% of all leukaemias and is the most common lymphoid malignancy in western countries. Standard treatments include mono- or polychemotherapies, usually combined with monoclonal antibodies such as rituximab or alemtuzumab. However, the impact of these agents remains unclear, as there are hints for increased risk of severe infections.<h4>Objectives</h4>The objectives of this review are to provide an evidence-based answer regarding ...[more]

PMID: 23152253

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