The role of GNLY gene polymorphisms in psoriasis pathogenesis.

ABSTRACT:

Background

Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granulysin (GNLY) is a cytolytic antimicrobial peptide (AMP) that is secreted together with granzyme and perforin from the granules of human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It has been immunohistochemically proven that the expression of granulysin is increased in lesions of psoriasis.

Objective

This study aimed to investigate the relationship between psoriasis disease and granulysin gene polymorphisms.

Methods

GNLY rs7908 and rs10180391 polymorphisms were s

SUBMITTER: Ermis E 

PROVIDER: S-EPMC6486070 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature