Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57^KIP2/Dacapo.

ABSTRACT: Quiescent neural stem cells (NSCs) in the adult brain are regenerative cells that could be activated therapeutically to repair damage. It is becoming apparent that quiescent NSCs exhibit heterogeneity in their propensity for activation and in the progeny that they generate. We discovered recently that NSCs undergo quiescence in either G₀ or G₂ in the Drosophila brain, challenging the notion that all quiescent stem cells are G₀ arrested. We found that G₂-quiescent NSCs become activated prior to G₀ NSCs. Here, we show that the cyclin-dependent kinase inhibitor Dacapo (Dap; ortholog of p57^KIP2) determines whether NSCs enter G₀ or G₂ quiescence during embryogenesis. We demonstrate that the dorsal patterning

SUBMITTER: Otsuki L 

PROVIDER: S-EPMC6486397 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature