Microduplications at the 15q11.2 BP1-BP2 locus are enriched in patients with anorexia nervosa.

ABSTRACT: Microduplication at 15q11.2 have been reported in genetic association studies of schizophrenia and autism. Given the potential overlap in psychiatric symptoms of schizophrenia and autism with anorexia nervosa (AN), we were inspired to test the association of this CNV locus with the genetic susceptibility of AN using ParseCNV, a highly quality controlled CNV pipeline developed by our group. The CNV analysis was performed in 1017 AN cases and 7250 controls using the Illumina HumanHap610 SNP arrays data. We uncovered association of the 15q11.2 microduplication with AN with P = 0.00023, while no genetic association between the microdeletion of this region and AN was identified. Among four genes in this region that are not imprinted, NIPA1 has the highest expression in brain and encodes a magne

SUBMITTER: Chang X 

PROVIDER: S-EPMC6486445 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature