Maternal postpartum plasma folate status and preterm birth in a high-risk US population.

ABSTRACT:

Objective

While maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. spontaneous and medically indicated PTB.

Design

Observational study.

Setting

Boston Birth Cohort, a predominantly urban, low-income, race/ethnic minority population at a high risk for PTB.ParticipantsMother-infant dyads (n 7675) enrolled in the Boston Birth Cohort. A sub-sample (n 2313) of these dyads had maternal plasma folate samples collected 24-72 h after delivery.

Results

Unadjusted and

SUBMITTER: Olapeju B 

PROVIDER: S-EPMC6486449 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature