PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination.

ABSTRACT: Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Here, in contrast, we show that citrullination by peptidylarginine deiminase 2 (PAD2) contributes to normal oligodendrocyte differentiation, myelination, and motor function. We identify several targets for PAD2, including myelin and chromatin-related proteins, implicating PAD2 in epigenomic regulation. Accordingly, we observe that PAD2 inhibition and its knockdown affect chromatin accessibility and prevent the upregulati

SUBMITTER: Falcao AM 

PROVIDER: S-EPMC6486480 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature