The Spectrum of Asynchronous Dynamics in Spiking Networks as a Model for the Diversity of Non-rhythmic Waking States in the Neocortex.

ABSTRACT: The awake cortex exhibits diverse non-rhythmic network states. However, how these states emerge and how each state impacts network function is unclear. Here, we demonstrate that model networks of spiking neurons with moderate recurrent interactions display a spectrum of non-rhythmic asynchronous dynamics based on the level of afferent excitation, from afferent input-dominated (AD) regimes, characterized by unbalanced synaptic currents and sparse firing, to recurrent input-dominated (RD) regimes, characterized by balanced synaptic currents and dense firing. The model predicted regime-specific relationships between different neural biophysical properties, which were all experimentally validated in the somatosensory cortex (S1) of awake mice. Moreover, AD regimes more precisely encoded spatio

SUBMITTER: Zerlaut Y 

PROVIDER: S-EPMC6486483 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature