A Biomechanical Model of Tumor-Induced Intracranial Pressure and Edema in Brain Tissue.

ABSTRACT: Brain tumor growth and tumor-induced edema result in increased intracranial pressure (ICP), which, in turn, is responsible for conditions as benign as headaches and vomiting or as severe as seizures, neurological damage, or even death. Therefore, it has been hypothesized that tracking ICP dynamics may offer improved prognostic potential in terms of early detection of brain cancer and better delimitation of the tumor boundary. However, translating such theory into clinical practice remains a challenge, in part because of an incomplete understanding of how ICP correlates with tumor grade. Here, we propose a multiphase mixture model that describes the biomechanical response of healthy brain tissue-in terms of changes in ICP and edema-to a growing tumor. The model captures ICP dynamics within

SUBMITTER: Sorribes IC 

PROVIDER: S-EPMC6486495 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature