Alterations in the gut microbiome and metabolism with coronary artery disease severity.

ABSTRACT:

Background

Coronary artery disease (CAD) is associated with gut microbiota alterations in different populations. Gut microbe-derived metabolites have been proposed as markers of major adverse cardiac events. However, the relationship between the gut microbiome and the different stages of CAD pathophysiology remains to be established by a systematic study.

Results

Based on multi-omic analyses (sequencing of the V3-V4 regions of the 16S rRNA gene and metabolomics) of 161 CAD patients and 40 healthy controls, we found that the composition of both the gut microbiota and metabolites changed significantly with CAD severity. We identified 29 metabolite modules that were separately classified as being positively or negatively correlated with CAD phenotypes, and the bacterial co-abun

SUBMITTER: Liu H 

PROVIDER: S-EPMC6486680 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature