Optogenetic reactivation of memory ensembles in the retrosplenial cortex induces systems consolidation.

ABSTRACT: The neural circuits underlying memory change over prolonged periods after learning, in a process known as systems consolidation. Postlearning spontaneous reactivation of memory-related neural ensembles is thought to mediate this process, although a causal link has not been established. Here we test this hypothesis in mice by using optogenetics to selectively reactivate neural ensembles representing a contextual fear memory (sometimes referred to as engram neurons). High-frequency stimulation of these ensembles in the retrosplenial cortex 1 day after learning produced a recent memory with features normally observed in consolidated remote memories, including higher engagement of neocortical areas during retrieval, contextual generalization, and decreased hippocampal dependence. Moreover, thi

SUBMITTER: de Sousa AF 

PROVIDER: S-EPMC6486739 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature