Structural insights into unique features of the human mitochondrial ribosome recycling.

ABSTRACT: Mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing proteins that are essential for oxidative phosphorylation (ATP generation). Despite their common ancestry with bacteria, the composition and structure of the human mitoribosome and its translational factors are significantly different from those of their bacterial counterparts. The mammalian mitoribosome recycling factor (RRF_mt) carries a mito-specific N terminus extension (NTE), which is necessary for the function of RRF_mt Here we present a 3.9-Å resolution cryo-electron microscopic (cryo-EM) structure of the human 55S mitoribosome-RRF_mt complex, which reveals α-helix and loop structures for the NTE that makes multiple mito-specific interactions with functionally critical re

SUBMITTER: Koripella RK 

PROVIDER: S-EPMC6486771 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature