Streptococcus gordonii programs epithelial cells to resist ZEB2 induction by Porphyromonas gingivalis.

ABSTRACT: The polymicrobial microbiome of the oral cavity is a direct precursor of periodontal diseases, and changes in microhabitat or shifts in microbial composition may also be linked to oral squamous cell carcinoma. Dysbiotic oral epithelial responses provoked by individual organisms, and which underlie these diseases, are widely studied. However, organisms may influence community partner species through manipulation of epithelial cell responses, an aspect of the host microbiome interaction that is poorly understood. We report here that Porphyromonas gingivalis, a keystone periodontal pathogen, can up-regulate expression of ZEB2, a transcription factor which controls epithelial-mesenchymal transition and inflammatory responses. ZEB2 regulation by P. gingivalis was mediated through

SUBMITTER: Ohshima J 

PROVIDER: S-EPMC6486779 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature