Structural basis for auxiliary subunit KCTD16 regulation of the GABA_B receptor.

ABSTRACT: Metabotropic GABA_B receptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABA_B receptor complexes contain the principal subunits GABA_B1 and GABA_B2, which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization domain-containing proteins (KCTDs). KCTDs interact with GABA_B receptors and modify the kinetics of GABA_B receptor signaling. Little is known about the molecular mechanism governing the direct association and functional coupling of GABA_B receptors with these auxiliary proteins. Here, we describe the high-resolution structure of the KCTD16 oligomerization domain in complex with part of the GABA_B2 receptor. A single GABA

SUBMITTER: Zuo H 

PROVIDER: S-EPMC6486783 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature