Recent Genetics and Epigenetics Approaches to PTSD.

ABSTRACT:

Purpose of review

Following a life-threatening traumatic exposure, about 10% of those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD), a severe and disabling syndrome characterized by uncontrollable intrusive memories, nightmares, avoidance behaviors, and hyperarousal in addition to impaired cognition and negative emotion symptoms. This review will explore recent genetic and epigenetic approaches to PTSD that explain some of the differential risk following trauma exposure.

Recent findings

A substantial portion of the variance explaining differential risk responses to trauma exposure may be explained by differential inherited and acquired genetic and epigenetic risk. This biological risk is complemented by alterations in the functional reg

SUBMITTER: Daskalakis NP 

PROVIDER: S-EPMC6486832 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature