Silk fibroin scaffolds seeded with Wharton's jelly mesenchymal stem cells enhance re-epithelialization and reduce formation of scar tissue after cutaneous wound healing.

ABSTRACT:

Background

The treatment of extensive and/or chronic skin wounds is a widespread and costly public health problem. Mesenchymal stem cells (MSCs) have been proposed as a potential cell therapy for inducing wound healing in different clinical settings, alone or in combination with biosynthetic scaffolds. Among them, silk fibroin (SF) seeded with MSCs has been shown to have increased efficacy in skin wound healing experimental models.

Methods

In this report, we investigated the wound healing effects of electrospun SF scaffolds cellularized with human Wharton's jelly MSCs (Wj-MSCs-SF) using a murine excisional wound splinting model.

Results

Immunohistopathological examination after transplant confirmed the presence of infiltrated human fibroblast-like CD90-positive cells

SUBMITTER: Millan-Rivero JE 

PROVIDER: S-EPMC6487033 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature