RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs.

ABSTRACT:

Background

Low back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a primary underlying role in causing such pain. Specifically, multiple independent endplate changes have been implicated in the initiation and progression of IVD degeneration.

Methods

In this study, we built a signaling network comprising both well-characterized IVD pathology-associated proteins as well as some potentially correlated proteins that have been associated with one or more of the currently known pathology-associated proteins. We then screened for the potential IVD degeneration-associated proteins using patients' normal and degenerative endplate specimens

SUBMITTER: Qiu X 

PROVIDER: S-EPMC6487042 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature