A Contagion Model for Within-Family Transmission of Drug Abuse.

ABSTRACT:

Objective

The purpose of this study was to determine whether, controlling for genetic effects, drug abuse was transmitted within families as predicted by a contagion model.

Methods

The authors examined 65,006 parent-offspring, sibling, and cousin pairs ascertained from Swedish population registries in which the primary case subject had a drug abuse registration. The rate of drug abuse registration among at-risk secondary case subjects ages 19-23 was studied. Utilizing matched control pairs, a difference-in-difference approach was used to infer causal effects.

Results

In offspring, risk for drug abuse registration in the 3 years after an index registration of a parent residing in the same household, neighborhood, or municipality increased 5.9%, 3.4%, and 1.8%, respecti

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC6487075 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature