Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.

ABSTRACT: Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites are ranked as the second leading cause of death worldwide by the World Health Organization. Despite tremendous improvements in global public health since 1950, a number of challenges remain to either prevent or eradicate infectious diseases. Many pathogens can cause acute infections that are effectively cleared by the host immunity, but a subcategory of these pathogens called "intracellular pathogens" can establish persistent and sometimes lifelong infections. Several of these intracellular pathogens manage to evade the host immune monitoring and cause disease by replicating inside the host cells. These pathogens have evolved diverse immune escape strategies and overcome immune responses by residing a

SUBMITTER: Thakur A 

PROVIDER: S-EPMC6487120 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature