Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons.

ABSTRACT: Neuropathic pain encompasses a diverse array of clinical entities affecting 7-10% of the population, which is challenging to adequately treat. Several promising therapeutics derived from molecular discoveries in animal models of neuropathic pain have failed to translate following unsuccessful clinical trials suggesting the possibility of important cellular-level and molecular differences between animals and humans. Establishing the extent of potential differences between laboratory animals and humans, through direct study of human tissues and/or cells, is likely important in facilitating translation of preclinical discoveries to meaningful treatments. Patch-clamp electrophysiology and RNA-sequencing was performed on dorsal root ganglia taken from patients with variable presence of radicula

SUBMITTER: North RY 

PROVIDER: S-EPMC6487328 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature