A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda.

ABSTRACT:

Background

Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-zoonotic form of the disease. Using a mathematical model with a 10 year time horizon, we demonstrate the role of the cattle treatment with trypanocides in the epidemiology of zoonotic and non-zoonotic HAT in Uganda, and its potential implications on elimination and eradication of the disease.

Methodology/principal findings

We created two compartmental, deterministic models, each comprised of three sub-models: humans, the tsetse fly vector (Glossina fuscipes fuscipes), and cattle. We applied these models to two HAT foci

SUBMITTER: Meisner J 

PROVIDER: S-EPMC6487357 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature