GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis.

ABSTRACT:

Background

Twin studies have demonstrated that both genetic and environmental factors influence risk for posttraumatic stress disorder (PTSD), and there is some evidence supporting the interplay of genes and environment (GxE). Many GxE studies within the PTSD literature have focused on genes implicated in the stress response system, such as FK506 binding protein 51 (FKBP5). Given inconsistencies across GxE literature as a whole, a meta-analysis to synthesize results is warranted.

Methods

Studies were identified through PubMed and PsycINFO. A meta-analysis was conducted using a random effects model in the MAc package in R. Heterogeneity of the effect size distribution was examined with Cochran's Q statistic. A Simes procedure was used to test the gene-level GxE effect for FKB

SUBMITTER: Hawn SE 

PROVIDER: S-EPMC6487483 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature