Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

ABSTRACT:

Introduction

Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria. They have major regulatory and signaling functions and seem dysregulated in Alzheimer's disease (AD).

Methods

Serum levels of 15 primary and secondary BAs and their conjugated forms were measured in 1464 subjects including 370 cognitively normal older adults, 284 with early mild cognitive impairment, 505 with late mild cognitive impairment, and 305 AD cases enrolled in the AD Neuroimaging Initiative. We assessed associations of BA profiles including selected ratios wit

SUBMITTER: MahmoudianDehkordi S 

PROVIDER: S-EPMC6487485 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature