Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.

ABSTRACT:

Background and purpose

Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration. Moreover, the associated impairment of autophagy greatly contributes to the aggravation of muscle damage. We explored the possibility of using non-euphoric compounds present in Cannabis sativa, cannabidiol (CBD), cannabidivarin (CBDV) and tetrahydrocannabidivarin (THCV), to reduce inflammation, restore functional autophagy and positively enhance muscle function in vivo.

Experimental approach

Using quantitative PCR, western blots and [Ca²⁺ ]_i measurements, we explored the effects of CBD and CBDV on the differentiation of both murine and human skeletal muscle cells as well as their potent

SUBMITTER: Iannotti FA 

PROVIDER: S-EPMC6487563 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature