Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers.

ABSTRACT:

Importance

Little progress in pediatric cancer treatment has been noted in the past decade, urging the development of novel therapeutic strategies for adolescents and children with hard-to-treat cancers. Use of comprehensive molecular profiling in the clinical management of children and adolescents with cancer appears a suitable approach to improve patient care and outcomes, particularly for hard-to-treat cases.

Objective

To assess the feasibility of identifying potentially actionable mutations using next-generation sequencing-based assays in a clinically relevant time frame.

Design, setting, and participants

This diagnostic study reports the results of the TRICEPS study, a prospective genome sequencing study conducted in Québec, Canada. Participants, aged 18 years or

SUBMITTER: Khater F 

PROVIDER: S-EPMC6487576 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature